Nuts and Bolts of Mass Spectrometry Short Course 2012
The short course is designed to develop understanding and key practical skills for early stage researchers in Earth Science who use sector-field, isotope ratio mass-spectrometry (i.e. multi-collector plasma, and thermal ionisation instruments).
Course Material
Mass Spectrometry (Chris Coath)
Ion Exchange Chemistry (Steve Noble)
Mass Fractionation and Calibration (Noah McLean)
COMING SOON - Statistics Part I (Marian Scott)
Statistics Part II (Noah McLean)
Uncertainty in Boron Isotope Measurements (James Rae)
Ion Exchange Chemistry (Steve Noble)
Mass Fractionation and Calibration (Noah McLean)
COMING SOON - Statistics Part I (Marian Scott)
Statistics Part II (Noah McLean)
Uncertainty in Boron Isotope Measurements (James Rae)
Tuesday, 17 January 2012
Monday, 9 January 2012
Friday, 6 January 2012
Short Course Location:
Lecture Theatre G25
Department of Earth Sciences
Wills Memorial Building (ground floor)
University of Bristol
http://www.bris.ac.uk/maps/print/precinct-key.pdf - Building 26.
Registration Monday 9th of January from 9.30am, first lecture starts 10am.
Department of Earth Sciences
Wills Memorial Building (ground floor)
University of Bristol
http://www.bris.ac.uk/maps/print/precinct-key.pdf - Building 26.
Registration Monday 9th of January from 9.30am, first lecture starts 10am.
Course Outline!
Day One: Hardware
Introduction
· Ion sources
· Mass analysers
· Detectors
· Examples of instruments
Ion optics
· Current and charge
· Electrostatic and Magnetic Fields
· Motion of charged particles
· Mass calibration and magnet control
· Geometric optics
· Focusing by electrostatic and magnetic sectors
· Energy (double) focusing
Measurement
· Peak shape
· Mass resolving power
· Nuclear mass defect
· Abundance sensitivity
· Faraday cups
Day Two: Calibration and Sample Preparation
Lecture 1: Introduction
Lecture 2: Reference Materials part I
Lecture 3: Reference Materials part II
Lecture 4. Methods for measuring U isotopic using TIMS and UF6 Mass spectrometry
Lecture 5. Isotope dilution and tracer calibration (mixed elemental and/or isotopic)
Lecture 6. Principles of sample analyses by microbeam methods (mainly LA-ICP-MS)
Lecture 7. Sample purification by ion exchange
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Short Course Dinner: Jamie’s Italian (top floor), 7.30 for 8.00.
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Day Three: Data reduction and Uncertainties
Lecture 1: the language of uncertainty, error, bias, precision, accuracy. What do they all mean?
Lecture 2: Measurement uncertainty-some basics
Lecture 3: Limits of detection, background evaluation and assessing performance
Lecture 4: Uncertainty/error propagation
Lecture 5: Over-determined systems
Some not so light reading...
H.E. Duckworth, R.C. Barber, and V.S. Venkatasubramanian. Mass Spectrometry 2nd ed. Cambridge (1990).
A. Septier. Focusing of Charged Particles. Vols I and II. Academic Press (1967).
M.E. Wieser and J.B. Schwieters. The development of multiple collector mass spectrometry for isotope ratio measurements. Int J. Mass Spectrom.
(2005) 242, 97-115
J.M. Hayes and D.A. Schoeller. High precision pulse counting:
liminations and optimal conditions. Anal. Chem. (1977), 49(2), 306-311.
A. Montaser. Inductively coupled plasma mass spectrometry. Wiley-VCH (1998).
John F. Rudge, Ben C. Reynolds, and Bernard Bourdon, The Double-Spike Toolbox, Chemical Geology (2009), 265, 420–431
Tuesday, 3 January 2012
Some light reading...
There are lots of great things to read in the Royal Society of Chemistry’s Analytical Methods Committee (AMC) Technical Briefs series:
#15 Is my uncertainty estimate realistic?
#13 Terminology - the key to understanding analytical science: Part 1: Accuracy, precision and uncertainty
#15 Is my uncertainty estimate realistic?
#13 Terminology - the key to understanding analytical science: Part 1: Accuracy, precision and uncertainty
Monday, 17 October 2011
Places to stay in Bristol
Professor Tim Elliott has suggested two of Bristols finest hotels to stay at whilst attending the short course...
Ibis: http://www.ibishotel.com/gb/hotel-5547-ibis-bristol-centre/index.shtml
Victoria Square Best Western: http://www.bestwestern.co.uk/Hotels/Victoria-Square-Hotel-Bristol-83700/Hotel-Info/Default.aspx
Ibis: http://www.ibishotel.com/gb/hotel-5547-ibis-bristol-centre/index.shtml
Victoria Square Best Western: http://www.bestwestern.co.uk/Hotels/Victoria-Square-Hotel-Bristol-83700/Hotel-Info/Default.aspx
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