Mass Spectrometry Short Course, Bristol, January 2012





  

Day One - ion counting, Chris tells it like it is...

Short Course Location:

Lecture Theatre G25
Department of Earth Sciences
Wills Memorial Building (ground floor)
University of Bristol


http://www.bris.ac.uk/maps/print/precinct-key.pdf - Building 26.


Registration Monday 9th of January from 9.30am, first lecture starts 10am.

Course Outline!

Day One:  Hardware

Introduction

·         Ion sources

·         Mass analysers

·         Detectors

·         Examples of instruments

Ion optics

·         Current and charge

·         Electrostatic and Magnetic Fields

·         Motion of charged particles

·         Mass calibration and magnet control

·         Geometric optics

·         Focusing by electrostatic and magnetic sectors

·         Energy (double) focusing

Measurement

·         Peak shape

·         Mass resolving power

·         Nuclear mass defect

·         Abundance sensitivity

·         Faraday cups

·         Ion couting

Day Two:  Calibration and Sample Preparation

Lecture 1: Introduction

Lecture 2: Reference Materials part I

Lecture 3: Reference Materials part II

Lecture 4. Methods for measuring U isotopic using TIMS and UF6 Mass spectrometry

Lecture 5. Isotope dilution and tracer calibration (mixed elemental and/or isotopic)

Lecture 6. Principles of sample analyses by microbeam methods (mainly LA-ICP-MS)

Lecture 7. Sample purification by ion exchange

*****************

Short Course Dinner: Jamie’s Italian (top floor), 7.30 for 8.00.

*****************

Day Three:   Data reduction and Uncertainties

Lecture 1: the language of uncertainty, error, bias, precision, accuracy.  What do they all mean?

Lecture 2:  Measurement uncertainty-some basics

Lecture 3:  Limits of detection, background evaluation and assessing performance

Lecture 4: Uncertainty/error propagation

Lecture 5: Over-determined systems

 

Some not so light reading...

H.E. Duckworth, R.C. Barber, and V.S. Venkatasubramanian. Mass Spectrometry 2nd ed. Cambridge (1990).

A. Septier. Focusing of Charged Particles. Vols I and II. Academic Press (1967).

M.E. Wieser and J.B. Schwieters. The development of multiple collector mass spectrometry for isotope ratio measurements. Int J. Mass Spectrom.

(2005) 242, 97-115

J.M. Hayes and D.A. Schoeller. High precision pulse counting:

liminations and optimal conditions. Anal. Chem. (1977), 49(2), 306-311.

A. Montaser. Inductively coupled plasma mass spectrometry. Wiley-VCH (1998).

John F. Rudge, Ben C. Reynolds, and Bernard Bourdon, The Double-Spike Toolbox, Chemical Geology (2009), 265, 420–431

Some light reading...

There are lots of great things to read in the Royal Society of Chemistry’s Analytical Methods Committee (AMC) Technical Briefs series:


#15 Is my uncertainty estimate realistic?

#13 Terminology - the key to understanding analytical science: Part 1: Accuracy, precision and uncertainty